General
Preferred name
Levistolide A
Synonyms
Diligustilide ()
Levistilide A ()
P&D ID
PD098266
CAS
88182-33-6
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Levistolide A is an apoptosis inducer and a PEDV virus inhibitor. Levistolide A can induce apoptosis in colon cancer cells and suppress the replication of porcine epidemic diarrhea virus (PEDV) by promoting ROS generation. Levistolide A activates peroxisome proliferator-activated receptor ¦Ã (PPAR¦Ã) in N2a/APP695swe cells and reduces excessive phosphorylation of tau through the GSK3¦Á/¦Â pathway, improving symptoms in Alzheimer¡¯s mice. Levistolide A improves kidney damage in 5/6 nephrectomy (Nx) mice by inhibiting the RAS,TGF-¦Â1/Smad, and MAPK pathways[1][2][3][4].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
380.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
6
Aromatic Ring Count
0
cLogP
5.13
TPSA
52.6
Fraction CSP3
0.58
Chiral centers
4.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
GSK-3
PPAR
Ras
Reactive Oxygen Species (ROS)
Tau Protein
TGF-β Receptor
P-gp
Reactive Oxygen Species
TGF-¦Â Receptor
Pathway
Cell Cycle/DNA Damage
GPCR/G protein
Immunology/Inflammation
MAPK/ERK Pathway
Metabolic Enzyme/Protease
Neuronal Signaling
NF-κB
PI3K/Akt/mTOR
Stem Cell/Wnt
TGF-beta/Smad
Vitamin D Related/Nuclear Receptor
NF-¦ÊB
Source data
