General
Preferred name
POMOLIC ACID
Synonyms
Randialic acid A ()
P&D ID
PD098230
CAS
13849-91-7
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC)[2].
PRICE 413
DESCRIPTION Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways. (TargetMol Bioactive Compound Library)
Cell lines
6
Organisms
1
Compound Sets
4
DrugMAP
DM1GV7K
MedChem Express Bioactive Compound Library
HY-N6601
Selleckchem Bioactive Compound Library
pomolic-acid
TargetMol Bioactive Compound Library
TN2097
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
472.36
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
0
cLogP
6.2
TPSA
77.76
Fraction CSP3
0.9
Chiral centers
10.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
AMPK
Apoptosis
Caspase
HIV
Apoptosis related
Pathway
Chromatin/Epigenetic
Microbiology/virology
PI3K/Akt/mTOR signaling
Proteases/Proteasome
Source data