General
Preferred name
Ec2la
Synonyms
CB2R PAM ()
compound C2 [PMID: 29990428] ()
P&D ID
PD098143
CAS
2244579-87-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Positive allosteric modulator (PAM) that targets CB2 receptors.
DESCRIPTION CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain[1].
PRICE 164
DESCRIPTION CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTP??S binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.
DESCRIPTION C2 is a positive allosteric modulator (PAM) that targets CB2 receptors. It has reported antinociceptive efficacy in an animal model of neuropathic pain . (GtoPdb)
DESCRIPTION Ec2la is a positive allosteric modulator of CB2 receptor. It enhances CP 55940 and 2-Arachidonylglycerol-stimulated binding of [35S]GTPγS to CB2 receptors, but doesn't have effect in the absence of agonist. (BOC Sciences Bioactive Compounds)
DESCRIPTION CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent TA1 receptor agonist (Tocris Bioactive Compound Library)
Compound Sets
8
BOC Sciences Bioactive Compounds
ec2la-cas-2244579-87-9-334127
Concise Guide to Pharmacology 2019/20
10273
Concise Guide to Pharmacology 2021/22
10273
Concise Guide to Pharmacology 2023/24
10273
Guide to Pharmacology
10273
MedChem Express Bioactive Compound Library
HY-131004
TargetMol Bioactive Compound Library
T37075
Tocris Bioactive Compound Library
6832
External IDs
6
Properties
(calculated by RDKit )
Molecular Weight
434.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
5.02
TPSA
51.1
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
7.0
QED
0.69
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CB2R
Cannabinoid Receptor
Primary Target
CB2 Receptors
MOA
Modulator
Pathway
GPCR/G protein
Neuronal Signaling
Solubility
DMSO: 8.71 mg/mL
Source data