General
Preferred name
Ec2la
Synonyms
CB2R PAM ()
compound C2 [PMID: 29990428] ()
P&D ID
PD098143
CAS
2244579-87-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Positive allosteric modulator (PAM) that targets CB2 receptors.
DESCRIPTION CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain[1].
PRICE 164
DESCRIPTION CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTP??S binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.
DESCRIPTION C2 is a positive allosteric modulator (PAM) that targets CB2 receptors. It has reported antinociceptive efficacy in an animal model of neuropathic pain . (GtoPdb)
DESCRIPTION Ec2la is a positive allosteric modulator of CB2 receptor. It enhances CP 55940 and 2-Arachidonylglycerol-stimulated binding of [35S]GTPγS to CB2 receptors, but doesn't have effect in the absence of agonist. (BOC Sciences Bioactive Compounds)
DESCRIPTION Potent TA1 receptor agonist (Tocris Bioactive Compound Library)
DESCRIPTION CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain. (TargetMol Bioactive Compound Library)
Compound Sets
9
BOC Sciences Bioactive Compounds
ec2la-cas-2244579-87-9-334127
Concise Guide to Pharmacology 2019/20
10273
Concise Guide to Pharmacology 2021/22
10273
Concise Guide to Pharmacology 2023/24
10273
Concise Guide to Pharmacology 2025/26
10273
Guide to Pharmacology
10273
MedChem Express Bioactive Compound Library
HY-131004
TargetMol Bioactive Compound Library
T37075
Tocris Bioactive Compound Library
6832
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
434.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
5.02
TPSA
51.1
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
7.0
QED
0.69
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CB2R
Cannabinoid Receptor
Primary Target
CB2 Receptors
MOA
Modulator
Pathway
GPCR/G protein
Neuronal Signaling
Solubility
DMSO: 8.71 mg/mL
Source data