General
Preferred name
Gusacitinib
Synonyms
ASN-002 ()
ASN002 ()
EN-3351 ()
EN3351 ()
Gusacitinib (ASN-002) ()
EN3351 hydrochloride ()
ASN002 hydrochloride ()
GUSACITINIB HYDROCHLORIDE ()
Gusacitinib ()
P&D ID
PD098126
CAS
1425381-60-7
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Eczema
Lymphoma
Drug Status
investigational
Max Phase
2.0
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Gusacitinib (ASN002) is an orally bioavailable dual spleen tyrosine kinase (SYK)/pan Janus kinase (JAK) inhibitor that is being developed by Asana BioSciences. It is being evaluated for clinical efficacy in inflammatory and oncology settings. Not to be confused with Ascend Biopharmaceuticals immuno-oncology lead ASN-002, which is an engineered virus that expresses IFN-γ.
Gusacitinib is one of the chemical structures (example 189) claimed in Asana Biosciences' patent WO2013028818A1 . (GtoPdb)
DESCRIPTION ASN-002 (Gusacitinib) is a dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with an IC50 value of 5-46 nM. It has anti-cancer activity. (BOC Sciences Bioactive Compounds)
Compound Sets
10
BOC Sciences Bioactive Compounds
asn-002-cas-1425381-60-7-373133
Cayman Chemical Bioactives
36554
ChEMBL Drugs
CHEMBL4594275
CHEMBL4594276
DrugBank
DB15670
DrugMAP
DM92X7N
Guide to Pharmacology
10000
MedChem Express Bioactive Compound Library
HY-103018
PKIDB
Selleckchem Bioactive Compound Library
gusacitinib
TargetMol Bioactive Compound Library
T14331
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
460.23
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
3
cLogP
2.55
TPSA
134.06
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Chromatin/Epigenetic
JAK/STAT Signaling
Stem Cells
Angiogenesis
Epigenetics
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Target
SYK
JAK
JAK,Syk
Solubility
Soluble in DMSO
Source data