General
Preferred name
Lerociclib
Synonyms
Lerociclib dihydrochloride ()
G1T38 dihydrochloride ()
G1T38 ()
G1T 38 ()
G1T-38 ()
Lerociclib (dihydrochloride) ()
G1T38 (dihydrochloride) ()
G1T38 FREE BASE ()
G1t38 ()
P&D ID
PD098104
CAS
1628256-23-4
2097938-59-3
Tags
available
drug candidate
Drug indication
Breast cancer
Non-small-cell lung cancer
non-small cell lung carcinoma
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Lerociclib (G1T38) is an investigational CDK4/6 inhibitor . It is being developed to help protect non-cancerous (normal) cells (in particular, hematopoietic stem and progenitor cells, and renal cells) in patients who are undergoing DNA damaging cancer chemotherapy . Lerociclib was designed to be highly selective, and short and transiently-acting.
(GtoPdb)
DESCRIPTION
Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 1 nM, 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively.
PRICE
123
PRICE
128
DESCRIPTION
Lerociclib is a novel, selective, and orally bioavailable CDK4/6 inhibitor with biochemical IC50 values of 1 nM, 2 nM and 28 μnM for CDK4, CDK6 and CDK9 respectively.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Lerociclib (G1T38) is a selective and highly potent CDK4/6 inhibitor with anticancer and antitumor activity, inhibits CDK4/CyclinD1 and CDK6/CyclinD3, and inhibits tumor growth in an animal model of endocrine-resistant breast cancer. Due to the poor solubility, for animal studies, the salt form T11345L is recommended.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective CDK4/CDK6 inhibitor, with IC50 values of 2 nM for CDK6/CyclinD3 and 1 nM for CDK4/CyclinD1.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Other bioactive compounds
PKIDB
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
474.29
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
6
Aromatic Ring Count
3
cLogP
3.5
TPSA
91.21
Fraction CSP3
0.54
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CDK
CDK4
CDK6
CDK1/cyclinB1
CDK2/CyclinA
CDK2/CyclinE
CDK4/CyclinD1
CDK5/p25
CDK5/p35
CDK6/CyclinD3
CDK7/Cyclin H/MAT1
CDK9/CyclinT
Pathway
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
Source data
