General
Preferred name
norendoxifen
Synonyms
P&D ID
PD096339
Tags
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Norendoxifen is an active metabolite of tamoxifen. In addition to acting as an estrogen receptor modulator, norendoxifen also inhibits aromatase enzyme activity (i.e. inhibits estrogen biosynthesis) . We show the Z isomer here as it is more potent in terms of ER modulation and in vivo activity compared to the E isomer. (GtoPdb)
Compound Sets
1
Guide to Pharmacology
10204
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
359.19
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
5.1
TPSA
55.48
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data