General
Preferred name
HISTIDINE
Synonyms
L-(-)-Histidine ()
L-histidine ()
L-Histidine monohydrochloride monohydrat ()
DL-Histidine-d3 ()
P&D ID
PD094120
CAS
71-00-1
96185-91-0
184709-11-3
5934-29-2
4998-57-6
344299-50-9
7048-02-4
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Histidine (abbreviated as His or H) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a charged, polar because of the hydrophilic nature of the imidazole side chain. L-Histidine is a positively charged (pKa 6.5) aromatic amino acid. Histidine residues are often found in enzyme active sites, where the chemistry of the imidazole ring of histidine makes it a nucleophile and a good acid/base catalyzer. Histidine is special in that its biosynthesis is inherently linked to the pathways of nucleotide formation. In the first step of histidine synthesis, PRPP (5-phosphoribosyl-alpha-pyrophosphate) condenses with ATP to form a purine, N1-5'-phosphoribosyl ATP, in a reaction that is driven by the subsequent hydrolysis of the pyrophosphate that condenses out. Glutamine plays a role as an amino group donor resulting in the formation of 5-aminoamidazole-4-carboximide ribonucleotide (ACAIR), which is an intermediate in purine biosynthesis. Hisitidne is catabolized by the enzyme histidine ammonia-lyase which converts histidine into ammonia and urocanic acid.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
46
Molecular Weight
155.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.64
TPSA
92.0
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
5.0
QED
0.54
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
MOA
Mitochondrial Metabolism
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data
