DESCRIPTION HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 28.1 ¦ÌM.

PRICE 105

DESCRIPTION HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 ??M).

DESCRIPTION HBX 19818 exhibited a dose-dependent effect on USP7 activity. HBX 19,818 efficiently blocked labeling of USP7 but not that of USP8, USP5, USP10, CYLD, or UCH-L3, showing this compound's specificity for USP7 over a panel of active DUBs under physiological conditions proved to be active in cells, as it almost completely inhibited USP7 labeling at 25 mM. MS/MS spectrum revealed that HBX 19,818 is attached to Cys315. Based on UV chromatogram (l = 332 nm) peak areas, HBX 19,818 partially reverses the deubiquitination of Mdm2 by USP7 in HEK293 cells, confirming that HBX 19,818 inhibits a biological activity of USP7 in living cells. HBX 19,818 has additional off-target, p53-independent proapoptotic effects. (BOC Sciences Bioactive Compounds)

DESCRIPTION HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM). (TargetMol Bioactive Compound Library)