General
Preferred name
TRYPTOPHOL
Synonyms
3-(2-Hydroxyethyl)indole ()
Indole-3-ethanol ()
2-(1H-Indol-3-yl)ethan-1-ol ()
P&D ID
PD088364
CAS
526-55-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy[1][2][3][4][5][6][7][8][9][10][11][12].
PRICE 29
DESCRIPTION Tryptophol is an endogenous metabolite. It inhibits indoleamine 2,3-dioxygenase 1, IC50 = 0.4µM. It has antiprotozoal, antineoplastic, antimicrobial activity. (Enamine Bioactive Compounds)
DESCRIPTION 2-(1H-Indol-3-yl)ethan-1-ol (3-(2-Hydroxyethyl)indole) is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
5
Cayman Chemical Bioactives
28404
Enamine Bioactive Compounds
EBC-47210
MedChem Express Bioactive Compound Library
HY-W010155
Selleckchem Bioactive Compound Library
tryptophol
TargetMol Bioactive Compound Library
T4876
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
161.08
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
1.7
TPSA
36.02
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Apoptosis
Bacterial
Caspase
Pathway
Metabolism
Anti-infection
Metabolic Enzyme/Protease
Source data