General
Preferred name
TETRAHYDROPIPERINE
Synonyms
Cosmoperine ()
5-(3,4-Methylenedioxyphenyl) Pentanoicacid Piperidine Amide ()
P&D ID
PD088141
CAS
23434-88-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tetrahydropiperine is an orally effective, selective inhibitor of NF-¦ÊB and MAPKs<¡¢b>, and an activator of the PI3K/Akt/mTOR<¡¢b> pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-¦Á, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-¦ÊB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke[1][2][3].
PRICE 29
DESCRIPTION Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
4
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
289.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
3.14
TPSA
38.77
Fraction CSP3
0.59
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CYP450
Cytochrome P450
hTRPV1
Pathway
Membrane Transporter/Ion Channel
Metabolism
Metabolic Enzyme/Protease
Source data