General
Preferred name
TETRAHYDROPIPERINE
Synonyms
Cosmoperine ()
5-(3,4-Methylenedioxyphenyl) Pentanoicacid Piperidine Amide ()
P&D ID
PD088141
CAS
23434-88-0
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tetrahydropiperine is an orally effective, selective inhibitor of NF-¦ÊB and MAPKs<¡¢b>, and an activator of the PI3K/Akt/mTOR<¡¢b> pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-¦Á, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-¦ÊB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke[1][2][3].
PRICE
29
DESCRIPTION
Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
4
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
289.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
3.14
TPSA
38.77
Fraction CSP3
0.59
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CYP450
Cytochrome P450
hTRPV1
Pathway
Membrane Transporter/Ion Channel
Metabolism
Metabolic Enzyme/Protease
Source data

