General
Preferred name
Chonglou Saponin VII
Synonyms
Paris saponin-VII ()
Paris saponin VII ()
Dioscinin, Polyphyllin-VII, Paris saponin-VII ()
Chonglou Saponin VII ()
P&D ID
PD088121
CAS
55916-45-5
68124-04-9
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1].
DESCRIPTION
Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
9
Molecular Weight
1030.53
Hydrogen Bond Acceptors
21
Hydrogen Bond Donors
11
Rotatable Bonds
9
Ring Count
10
Aromatic Ring Count
0
cLogP
-0.79
TPSA
314.83
Fraction CSP3
0.96
Chiral centers
31.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Autophagy
Chromatin/Epigenetic
Cytoskeletal Signaling
DNA Damage/DNA Repair
MAPK
Membrane Transporter/Ion Channel
Neuroscience
PI3K/Akt/mTOR signaling
Proteases/Proteasome
Cell Cycle/DNA Damage
Epigenetics
MAPK/ERK Pathway
PI3K/Akt/mTOR
Target
Akt
Bcl-2 Family
Caspase
p38 MAPK
PARP
P-glycoprotein
GSK-3
P-gp (P-glycoprotein)
Source data
