General
Preferred name
Engeletin
Synonyms
Dihydrokaempferol 3-rhamnoside ()
P&D ID
PD088110
CAS
572-31-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-¦ÊB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
PRICE 60
DESCRIPTION 1. Engeletin (Dihydrokaempferol 3-rhamnoside) may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 ??g/ml. 3. Engeletin inhibits a recombinant human aldose reductase (IC5 value=1.16 microM).
DESCRIPTION 1. Engeletin (Dihydrokaempferol 3-rhamnoside) may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a recombinant human aldose reductase (IC5 value=1.16 microM). (TargetMol Bioactive Compound Library)
Compound Sets
4
Cayman Chemical Bioactives
34657
MedChem Express Bioactive Compound Library
HY-N0436
Selleckchem Bioactive Compound Library
engeletin
TargetMol Bioactive Compound Library
T6S0840
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
434.12
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
6
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
0.33
TPSA
166.14
Fraction CSP3
0.38
Chiral centers
7.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
NF-??
Endocrinology/Hormones
Metabolism
Target
NF-κB
Aldose Reductase
MOA
Reductase
Source data