General
Preferred name
AS057278
Synonyms
3-Methylpyrazole-5-carboxylic acid ()
5-Methyl-1H-pyrazole-3-carboxylic acid ()
P&D ID
PD088085
CAS
696-22-0
402-61-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 ¦ÌM and EC50 of 2.2-3.95 ¦ÌM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia[1].
PRICE 35
DESCRIPTION AS057278 (3-Methylpyrazole-5-carboxylic acid) is an D-amino acid oxidase (DAAO) inhibitor.
DESCRIPTION 5-Methyl-1H-pyrazole-3-carboxylic acid is a potent and selective D-amino acid oxidase inhibitor. (Enamine Bioactive Compounds)
DESCRIPTION Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
5
Enamine Bioactive Compounds
EBC-47545
EU-OPENSCREEN Bioactive Compound Library
EOS102252
MedChem Express Bioactive Compound Library
HY-33009
Selleckchem Bioactive Compound Library
as057278
TargetMol Bioactive Compound Library
K780-0839
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
126.04
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
0.42
TPSA
65.98
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
5.0
QED
0.57
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data