General
Preferred name
TOMATINE
Synonyms
LYCOPERSICIN ()
Tomatine ()
¦Á-Tomatine ()
α-Tomatine ()
Tomatin ()
P&D ID
PD088019
CAS
17406-45-0
Tags
available
drug candidate
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity[1].
DESCRIPTION
Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
1033.55
Hydrogen Bond Acceptors
22
Hydrogen Bond Donors
13
Rotatable Bonds
11
Ring Count
10
Aromatic Ring Count
0
cLogP
-2.7
TPSA
337.86
Fraction CSP3
1.0
Chiral centers
31.0
Largest ring
6.0
QED
0.09
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Proteasome
Fungal
Therapeutic Class
Antimicrobial Agents
Pathway
Proteases/Proteasome
Ubiquitination
Metabolic Enzyme/Protease
Source data
