General
Preferred name
FLAVOKAWAIN A
Synonyms
Flavokavain A ()
FLAVOKAVAIN A(P) ()
(E)-Flavokawain A ()
2'-HYDROXY-4, 4', 6'-TRIMETHOXYCHALCONE ()
Flavokawain A (CRM) ()
P&D ID
PD087997
CAS
3420-72-2
37951-13-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Flavokawain A is a chalcone compound and an orally active inhibitor of PRMT5 and cytochrome P450. Flavokawain A has anti-inflammatory, anti-tumor, and immunomodulatory effects. Flavokawain A can inhibit the proliferation of tumor cells and induce apoptosis. Flavokawain A can be used in the research of diseases such as bladder cancer[1][2][3][4][5].
DESCRIPTION (E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice[1].
PRICE 29
PRICE 47
DESCRIPTION NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-??B-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.
DESCRIPTION NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages. (TargetMol Bioactive Compound Library)
DESCRIPTION (E)-Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. (TargetMol Bioactive Compound Library)
Cell lines
9
Organisms
1
Compound Sets
5
Cayman Chemical Bioactives
36083
40957
MedChem Express Bioactive Compound Library
HY-N2420
HY-N5106
Other bioactive compounds
Selleckchem Bioactive Compound Library
e-flavokawain-a
flavokawain-a
TargetMol Bioactive Compound Library
T3S0737
T5715
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
314.12
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
3.31
TPSA
64.99
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
p38
CYP450
Akt
Caspase
COX
Cytochrome P450
ERK
Histone methyltransferase
IAP
NO Synthase
PI3K
Survivin
Bcl-2,IAP,Survivin
Apoptosis related
MOA
p38 MAPK
NF-¦ÊB
JNK
Pathway
Epigenetics
Immunology/Inflammation
MAPK/ERK Pathway
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
Stem Cell/Wnt
MAPK
Metabolism
Source data