General
Preferred name
MICHELIOLIDE
Synonyms
P&D ID
PD087849
CAS
68370-47-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-¦ÊB activation, I¦ÊB¦Á degradation, and the expression of MCP-1, TGF-¦Â1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-¦ÊB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis[1][2][3][4].
PRICE 121
DESCRIPTION Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs). (BOC Sciences Bioactive Compounds)
DESCRIPTION Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
6
BOC Sciences Bioactive Compounds
micheliolide-cas-68370-47-8-item-84-463310
Cayman Chemical Bioactives
25402
Guide to Pharmacology
13701
MedChem Express Bioactive Compound Library
HY-N0847
Selleckchem Bioactive Compound Library
micheliolide
TargetMol Bioactive Compound Library
T5688
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
248.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
0
cLogP
2.36
TPSA
46.53
Fraction CSP3
0.67
Chiral centers
4.0
Largest ring
7.0
QED
0.41
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
COX-2
Inos
NF-κB
Akt
PI3K
TGF-beta/Smad
Immunology & Inflammation related
Pathway
Immunology/Inflammation
Neuroscience
PI3K/Akt/mTOR
Stem Cell/Wnt
NF-¦ÊB
Source data