General
Preferred name
DAPHNORETIN
Synonyms
Dephnoretin ()
Thymelol ()
Dephnoretin, Thymelol ()
P&D ID
PD087647
CAS
2034-69-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity[1]. Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst[2].
PRICE 58
DESCRIPTION 1. Daphnoretin (Thymelol) has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through promoting apoptosis in a mitochondria-mediated way. 3. Daphnoretin causes death of HOS cells by blocking cells successively in G2/M phases and activating the caspase-3 pathway. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
4
Cayman Chemical Bioactives
26408
MedChem Express Bioactive Compound Library
HY-N0699
Selleckchem Bioactive Compound Library
daphnoretin
TargetMol Bioactive Compound Library
T4S1335
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
352.06
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
4
cLogP
3.41
TPSA
99.11
Fraction CSP3
0.05
Chiral centers
0.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
caspase-3
Influenza Virus
PKC
Akt,Apoptosis related,PKC
MOA
Caspase
Pathway
Apoptosis
Chromatin/Epigenetic
Cytoskeletal Signaling
Microbiology/virology
Proteases/Proteasome
Anti-infection
Epigenetics
TGF-beta/Smad
Source data