General
Preferred name
Saikosaponin B2
Synonyms
Saikosaponin B2 ()
P&D ID
PD087362
CAS
58316-41-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Saikosaponin B2 is an active component from Bupleurum chinensis root, acts as an entry inhibitor against HCV infection[1]. Anti-cancer activity[2].
PRICE 180
DESCRIPTION Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2 (5 ??M) induces differentiation of B16 melanoma cells, with potentiation of expressions of tyrosinase and melanogenesis.
DESCRIPTION Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2 (5 μM) induces differentiation of B16 melanoma cells, with potentiation of expressions of tyrosinase and melanogenesis. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
2
Compound Sets
4
Cayman Chemical Bioactives
39936
MedChem Express Bioactive Compound Library
HY-N0248
Selleckchem Bioactive Compound Library
saikosaponin-b2
TargetMol Bioactive Compound Library
T3810
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
780.47
Hydrogen Bond Acceptors
13
Hydrogen Bond Donors
9
Rotatable Bonds
7
Ring Count
7
Aromatic Ring Count
0
cLogP
1.68
TPSA
218.99
Fraction CSP3
0.9
Chiral centers
19.0
Largest ring
6.0
QED
0.17
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HCV
Antiviral
MOA
Others inhibitor
Pathway
Anti-infection
Microbiology/virology
Proteases/Proteasome
Source data