General
Preferred name
Angelic Acid
Synonyms
2-Methylisocrotonic acid ()
(Z)-2-Methylbut-2-enoic acid ()
cis-2-Methyl-2-butenoic acid ()
P&D ID
PD087240
CAS
565-63-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity[1][2].
PRICE 29
DESCRIPTION Angelic Acid ((Z)-2-Methylbut-2-enoic acid) is a monocarboxylic unsaturated organic acid. Angelic acid esters are the active components of herbal medicine used against a wide range of various health disturbances including pains, fever, gout, heartburn, etc. (TargetMol Bioactive Compound Library)
Compound Sets
3
MedChem Express Bioactive Compound Library
HY-N6929
Selleckchem Bioactive Compound Library
angelic-acid
TargetMol Bioactive Compound Library
T3328
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
100.05
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
0
Aromatic Ring Count
0
cLogP
1.04
TPSA
37.3
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
0.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data