General
Preferred name
LEVOFLOXACIN
Synonyms
Levaquin hydrate ()
Cravit hydrate ()
Quixin hydrate ()
Levofloxacin Hemihydrate ()
Tavanic hydrate ()
Iquix hydrate ()
Levofloxacin hydrate ()
Levofloxacin (hydrate) ()
Quixin ()
L-ofloxacin ()
Levofloxacin (as hemihydrate) ()
DR-3355 ()
Levaquin ()
Tavanic ()
RWJ-25213 ()
Quinsair ()
Cravit ()
Ofloxacin s-(-)-form hemihydrate ()
Ofloxacin, (s)- ()
Oftaquix ()
Volequin ()
Iquix ()
Evoxil ()
Nofaxin ()
P&D ID
PD087124
CAS
138199-71-0
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Chronic bronchitis
First approval
1996
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
9
Compound Sets
5
AdooQ Bioactive Compound Library
A16167
Cayman Chemical Bioactives
20382
ChEMBL Approved Drugs
CHEMBL5315124
ChEMBL Drugs
CHEMBL5315124
TargetMol Bioactive Compound Library
T1451
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
740.3
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
8
Aromatic Ring Count
4
cLogP
2.26
TPSA
181.52
Fraction CSP3
0.44
Chiral centers
2.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
DNA gyrase
Topo II
Topo IV
Pathway
DNA Damage/DNA Repair
Microbiology/virology
Source data