General
Preferred name
Artemitin
Synonyms
ARTEMETIN ()
Artemisetin ()
Erianthin ()
P&D ID
PD086982
CAS
479-90-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED50 of 5-10 ¦Ìg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED50 of 1.6 ¦Ìg/kg, and has analgesic activity[1][2][3].
PRICE 104
DESCRIPTION 1. Artemitin (Erianthin) has anti-inflammatory activity. 2. Artemitin (Erianthin) protects endothelial function by acting as antioxidant and antiapoptotic agent and through the activation of ERK1/2 and Akt. 3. Intravenous injection of Artemitin (Erianthin)(.75 mg/kg) significantly reduces the hypertensive response to angiotensin I while increases the average length of bradykinin-induced hypotension. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
1
Compound Sets
4
Cayman Chemical Bioactives
40269
MedChem Express Bioactive Compound Library
HY-N3017
Selleckchem Bioactive Compound Library
artemitin
TargetMol Bioactive Compound Library
TCS1704
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
388.12
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.21
TPSA
96.59
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
antioxidant
antibiotic
MOA
Antioxidant
Pathway
Anti-infection
oxidation-reduction
Source data