General
Preferred name
TL6-144
Synonyms
JAK3-IN-1 ()
P&D ID
PD086788
CAS
1805787-93-2
Tags
probe
covalent binder
available
Probe info
Probe type
experimental probe
Probe sources
Gray Laboratory Probes
High-quality chemical probes
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
7
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
507.21
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
3
cLogP
4.37
TPSA
94.65
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
JAK3
JAK
Pathway
Epigenetics
JAK/STAT Signaling
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Source data
