General
Preferred name
CCT251921
Synonyms
cmpd 109 ()
CCT-251921 ()
P&D ID
PD086744
CAS
1607837-31-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2.3 nM.
PRICE 303
DESCRIPTION CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor [IC50: 2.3 nM]. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
7
CDK inhibitor database (CDKiDB)
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
EOS100986
Kinase Chemogenomic Set (KCGS)
CCT251921
MedChem Express Bioactive Compound Library
HY-19984
TargetMol Bioactive Compound Library
T14901
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
410.16
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
3
cLogP
2.98
TPSA
89.07
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CDK
CDK19
CDK8
CDK8, CDK19
Pathway
Cell Cycle/Checkpoint
Cell Cycle/DNA Damage
Source data