General
Preferred name
TRICIRIBINE PHOSPHATE
Synonyms
triciribine ()
Phosphate Salt Of Tricyclic Nucleoside, Triciribine Phosphate, VQD-002 ()
TCN-P ()
VD 002 ()
VQD-002 ()
Phosphate Salt Of Tricyclic Nucleoside ()
Triciribina ()
NSC-154020 ()
NSC-280594 ()
Triciribine ()
Triciribine Phosphate ()
P&D ID
PD086723
CAS
61966-08-3
Tags
drug candidate
available
Drug indication
Acute myeloid leukaemia
Leukemia
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 703
DESCRIPTION Triciribine phosphate (VD 002) is a highly selective AKT inhibitor that induces cell cycle arrest and cysteinyl asparagin-dependent apoptosis, inhibits neovascularization, and can be used in the study of leukemia. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
3
Compound Sets
9
AdooQ Bioactive Compound Library
A11033
Cayman Chemical Bioactives
37985
ChEMBL Drugs
CHEMBL462018
Clinical kinase drugs
Drug Repurposing Hub
DrugBank
DB14636
DrugMAP
DMV0AH8
ReFrame library
TargetMol Bioactive Compound Library
T19699
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
400.09
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
5
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
-1.77
TPSA
188.78
Fraction CSP3
0.46
Chiral centers
4.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
AKT1
Target
Apoptosis
Akt
MOA
Akt inhibitor
Pathway
Cytoskeletal Signaling
PI3K/Akt/mTOR signaling
Source data