General
Preferred name
GLPG-1837
Synonyms
ABBV-974 ()
GLPG1837 ()
P&D ID
PD086682
CAS
1654725-02-6
Tags
available
drug candidate
Drug indication
Cystic fibrosis
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GLPG1837 is a CFTR potentiator class agent for cystic fibrosis patients with the CFTRG551D variant . (GtoPdb)
DESCRIPTION GLPG1837 is a potent, orally available potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively. (BOC Sciences Bioactive Compounds)
Compound Sets
12
AdooQ Bioactive Compound Library
A19522
BOC Sciences Bioactive Compounds
glpg1837-cas-1654725-02-6-334101
Cayman Chemical Bioactives
9003143
Drug Repurposing Hub
DrugBank
DB16835
DrugMAP
DMOCRYB
Guide to Pharmacology
12735
Mcule NIBR MoA Box Subset
MCULE-3045529702
MedChem Express Bioactive Compound Library
HY-111099
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
glpg1837
TargetMol Bioactive Compound Library
T7083
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
348.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
2.41
TPSA
110.1
Fraction CSP3
0.44
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Autophagy
Target
CFTR
MOA
CFTR potentiator
CFTR modulator
CFTR channel potentiator
Member status
virtual
Source data