General
Preferred name
ISPRONICLINE
Synonyms
RJR-1734 ()
AZD3480 ()
AZD-3480 ()
AZD 3480 ()
TC 1734 ()
TC-01734 ()
TC-1734 ()
ACD3480 ()
Isproniclina ()
Azd3480 ()
ISPRONICLINA ()
P&D ID
PD086136
CAS
252870-53-4
Tags
available
drug candidate
Drug indication
Schizophrenia
Attention deficit hyperactivity disorder
Alzheimer disease
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ispronicline (TC-1734), an orally active, brain-selective ¦Á4¦Â2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the ¦Á4¦Â2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as ¦Á7 nAChR and ¦Á3¦Â4 nAChR[1][2].
DESCRIPTION Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.Ispronicline has a high affinity for the α4β2 nAChR with a Ki= 11 nM. (TargetMol Bioactive Compound Library)
Compound Sets
8
ChEMBL Drugs
CHEMBL188462
DrugBank
DB16205
DrugMAP
DMKY2UE
EUbOPEN Chemogenomics Library
EUB0001948
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL188462
MedChem Express Bioactive Compound Library
HY-10063
ReFrame library
TargetMol Bioactive Compound Library
T27636
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
234.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
2.88
TPSA
34.15
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
α4β2 nAChR
nAChR
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Recommended Cell Concentration
None
Source data