General
Preferred name
GSK189254
Synonyms
6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide ()
GSK-189254 ()
GSK189254A ()
GSK 189254 ()
P&D ID
PD086011
CAS
720690-73-3
Tags
available
drug candidate
Drug indication
Cognitive impairment
Drug Status
investigational
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent and selective H3 histamine receptor inverse agonist. Radioligand 11C-GSK189254 can be used to quantify H3 receptor availability in humans in vivo using PET. (GtoPdb)
Compound Sets
13
Cayman Chemical Bioactives
36705
ChEMBL Drugs
CHEMBL517140
Concise Guide to Pharmacology 2021/22
10736
Concise Guide to Pharmacology 2023/24
10736
Drug Repurposing Hub
DrugMAP
DMKXPOL
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100200
Guide to Pharmacology
10736
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL517140
MedChem Express Bioactive Compound Library
HY-14111
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
351.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
3.76
TPSA
57.95
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
7.0
QED
0.67
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Member status
member
MOA
Histamine H3 Receptor Inverse Agonists
Histamine H3 Receptor Antagonists
Histamine Receptor antagonist
Pathway
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Target
Histamine Receptor
Source data