General
Preferred name
MILVETEROL
Synonyms
GSK-159797 ()
GSK 159797 ()
GSK159797 ()
MILVETEROL HYDROCHLORIDE ()
Milveterol HCl ()
TD3327 ()
GSK-159797C ()
GSK159797C ()
Milveterol hcl ()
P&D ID
PD085931
CAS
652990-07-3
804518-03-4
Tags
available
drug candidate
Drug indication
Chronic obstructive pulmonary disease
Asthma
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 453
DESCRIPTION Milveterol HCl is a long-acting ??(2) -adrenergic receptor agonist for the potential treatment of chronic obstructive pulmonary disease (COPD).
DESCRIPTION Milveterol is a long-acting β(2)-adrenoceptor agonist. It is potentially useful for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. It was developed by GlaxoSmithKline and Theravance together. It was in clinic phase 2 trials, but now it is terminated. (BOC Sciences Bioactive Compounds)
DESCRIPTION Milveterol is a long-acting β(2)-adrenoceptor agonist under the development of GlaxoSmithKline. Phase II trials for the treatment of Chronic obstructive pulmonary disease were discontinued. (BOC Sciences Bioactive Compounds)
DESCRIPTION Milveterol HCl is a long-acting β(2) -adrenergic receptor agonist for the potential treatment of chronic obstructive pulmonary disease (COPD). (TargetMol Bioactive Compound Library)
Compound Sets
6
BOC Sciences Bioactive Compounds
milveterol-cas-652990-07-3-item-476084
milveterol-hydrochloride-cas-804518-03-4-item-459711
ChEMBL Drugs
CHEMBL1940832
CHEMBL2107356
DrugMAP
DMF1IH5
DMTZBXQ
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1940832
ReFrame library
TargetMol Bioactive Compound Library
T33386
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
435.22
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
6
Rotatable Bonds
11
Ring Count
3
Aromatic Ring Count
3
cLogP
3.62
TPSA
117.34
Fraction CSP3
0.24
Chiral centers
2.0
Largest ring
6.0
QED
0.16
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
β2-adrenergic receptor
Pathway
GPCR/G protein
Neuroscience
Solubility
Soluble in DMSO
Soluble in DMSO, not in water
Source data