General
Preferred name
SIMETHICONE
Synonyms
P&D ID
PD085725
CAS
8050-81-5
Tags
available
drug
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Simethicone acts by decreasing the surface tension of gas bubbles, thus facilitating their coalescence and expulsion as flatus or belching.; It also prevents the formation and accumulation of mucus-enclosed pockets of gas in digestive tract. ; Simethicone also facilitates the passage of gas through bowel lumen and allows patients to excrete a greater volume of gas at one time, thereby reducing the number of flatus events.
INDICATION 1. To relieve pain and discomfort caused by excess gas in the intestine and stomach in cases such as flatulence and post operative gaseous distention.; 2. It could be used also prior to an endoscopy to eliminate foam, gas and air from the gastrointestinal tract to reduce gas shadow which will result in better visualization.
Compound Sets
2
DrugBank
DB09512
DrugBank Approved Drugs
DB09512
External IDs
7
Properties
(calculated by RDKit )
Molecular Weight
238.05
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
1.57
TPSA
52.6
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.7
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data