General
Preferred name
PRLX-93936
Synonyms
PRLX-93936 hcl(903499-49-0 Free base) ()
PRLX-93936 (dihydrochloride) ()
PRLX 96936 ()
PRLX-93936 HCL ()
P&D ID
PD085562
CAS
1094210-96-4
903499-49-0
Tags
available
molecular glue
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PRLX-93936 dihydrochloride (Compound 16) is a HIF-1¦Á inhibitor with anticancer activity. PRLX-93936 can inhibit the activated Ras pathway and can be used in the study of relapsed or refractory multiple myeloma[1][2].
PRICE
514
DESCRIPTION
PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
Cayman Chemical Bioactives
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
MolGlueDB
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
364.19
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
2.19
TPSA
59.39
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HIF/HIF Prolyl-Hydroxylase
Ras
Ferroptosis
Reactive Oxygen Species
MOA
voltage-dependent anion selective channel protein inhibitor
Pathway
GPCR/G protein
MAPK/ERK Pathway
Metabolic Enzyme/Protease
Apoptosis
Immunology/Inflammation
Metabolism
NF-κB
Source data
