General
Preferred name
AC1903
Synonyms
AC 1903 ()
P&D ID
PD085517
CAS
831234-13-0
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model[1].
PRICE
45
DESCRIPTION
AC1903 is small-molecule inhibitor of TRPC5 ion channels that has demonstrated in vivo activity .
(GtoPdb)
DESCRIPTION
AC1903 is a specific and selective inhibitor of TRPC5. It is selective for TRPC5 over TRPC4 and TRPC6.
(Enamine Bioactive Compounds)
DESCRIPTION
AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5; IC50 = 14.7 µM).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.
(TargetMol Bioactive Compound Library)
DESCRIPTION
CaV3.2 and CaV3.1 channel blocker; orally bioavailable
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
11
Molecular Weight
303.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
4
cLogP
4.29
TPSA
42.99
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
TRP Channel
TRPC5
TRPC5 blocker
Primary Target
TRPC
MOA
Blocker
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
