General
Preferred name
PROCYANIDIN C1
Synonyms
PCC1 ()
Procyanidin C2 ()
P&D ID
PD085487
CAS
37064-30-5
Tags
available
natural product
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice[1][2].
PRICE 693
DESCRIPTION Procyanidin C2 is a bitter tasting natural produst that is found in Vitis vinifera (grapes) and the flowering plant Potentilla longifolia. Structurally it contains 3 linked (+)-catechin molecules. (GtoPdb)
DESCRIPTION Procyanidin C1 is a natural polyphenol that causes DNA damage, cell cycle arrest, and apoptosis induction. It reduces Bcl-2 protein levels and enhances the expression of BAX, caspase 3, and 9 in cancer cells. (TargetMol Bioactive Compound Library)
Compound Sets
5
Cayman Chemical Bioactives
25201
Concise Guide to Pharmacology 2023/24
12426
Guide to Pharmacology
12426
MedChem Express Bioactive Compound Library
HY-N2342
TargetMol Bioactive Compound Library
TN2103
External IDs
50
Properties
(calculated by RDKit )
Molecular Weight
866.21
Hydrogen Bond Acceptors
18
Hydrogen Bond Donors
15
Rotatable Bonds
5
Ring Count
9
Aromatic Ring Count
6
cLogP
4.44
TPSA
331.14
Fraction CSP3
0.2
Chiral centers
8.0
Largest ring
6.0
QED
0.11
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Apoptosis protein
Source data