General
Preferred name
AZ PFKFB3 67
Synonyms
AZ-PFKFB3-67 ()
P&D ID
PD080291
CAS
1704741-11-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1, respectively. AZ-PFKFB3-67 reduces MCL-1. AZ-PFKFB3-67 has neuroprotective activity[1][2][3].
PRICE 32
DESCRIPTION AZ-PFKFB3-67 is a novel, potent and selective inhibitor of PFKFB3.
DESCRIPTION AZ PFKFB3 67 is a selective and novel metabolic kinase PFKFB3 inhibitor with IC50 value of 11 μM. (BOC Sciences Bioactive Compounds)
DESCRIPTION Cdc20 inhibitor; inhibits Cdc20-substrate interaction (Tocris Bioactive Compound Library)
Compound Sets
6
BOC Sciences Bioactive Compounds
az-pfkfb3-67-cas-1704741-11-6-item-169686
Cayman Chemical Bioactives
43952
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
HY-101972
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
5742
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
455.2
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
4
cLogP
4.65
TPSA
105.11
Fraction CSP3
0.27
Chiral centers
1.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
PFKFB3
MOA
Inhibitor
inhibition of PFKFB3 leads to inhibition of glycolysis
PFKFB3 inhibitor
Member status
member
Pathway
Apoptosis
Metabolic Enzyme/Protease
Target
Bcl-2 Family
phosphatase
Source data