General
Preferred name
RA839
Synonyms
RA 839 ()
RA-839 ()
P&D ID
PD079874
CAS
1832713-02-6
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
RA839 is a selective Nrf2/ARE pathway agonist and non-covalent small molecule binder of Keap1 (Kd is approximately 6 ¦ÌM). RA839 prevents inducible nitric oxide synthase expression and nitric oxide release. RA839 exerts anti-rotaviral and anti-inflammatory effects[1][2].
PRICE
183
DESCRIPTION
RA839 is a small molecule that noncovalently interacts with KEAP1 and acts as a selective activator of Nrf2-mediated gene transcription . RA839-induced activation of the Nrf2/ARE pathway is reported to produce an anti-rotaviral effect, via inhibition of rotavirus propagation, in vitro .
(GtoPdb)
DESCRIPTION
RA 839 is a selective inhibitor of the Keap1/Nrf2 interaction (Kd=6 uM) and a useful tool compound to study the biology of Nrf2. It binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM. RA 839 suppresses LPS-induced iNOS and nitric oxide expression in macrophages.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.RA-839 inhibits the expression of inducible nitric oxide synthase and inhibits nitric oxide release.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Inhibits Mcl-1-BIM interaction
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
BOC Sciences Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
11
Molecular Weight
452.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
4.79
TPSA
86.71
Fraction CSP3
0.32
Chiral centers
1.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Keap1-Nrf2
NO Synthase
Primary Target
Nrf2
MOA
Activator
Pathway
Immunology/Inflammation
NF-κB
NF-¦ÊB
Source data
