General
Preferred name
ZINTEROL HYDROCHLORIDE
Synonyms
Zinterol (hydrochloride) ()
MJ 9184 (hydrochloride) ()
MJ-9184-1 ()
MJ 9184-1 ()
ZINTEROL HCL ()
NSC-284704 ()
ZINTEROL ()
P&D ID
PD078988
CAS
38241-28-0
79561-61-8
Tags
available
drug candidate
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective ¦Â2-adrenoceptor agonist[1]. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits[3].
DESCRIPTION Zinterol hydrochloride is a potent and selective β2-adrenoceptor agonist (pKB = 8.3 and < 5.7 for β 2 and β1 receptors respectively, as measured in human artery). (BOC Sciences Bioactive Compounds)
DESCRIPTION alpha1A agonist (Tocris Bioactive Compound Library)
Compound Sets
5
BOC Sciences Bioactive Compounds
zinterol-hydrochloride-cas-38241-28-0-371694
ChEMBL Drugs
CHEMBL2105510
EUbOPEN Chemogenomics Library
EUB0000482
MedChem Express Bioactive Compound Library
HY-14304A
Tocris Bioactive Compound Library
1051
External IDs
9
Properties
(calculated by RDKit )
Molecular Weight
414.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
2.83
TPSA
98.66
Fraction CSP3
0.37
Chiral centers
1.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Adrenergic ?2 Receptors
MOA
Agonist
Target
Adrenergic Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Recommended Cell Concentration
1 nM
Source data