General
Preferred name
CHELIDONINE
Synonyms
Stylophorin ()
Khelidonin ()
Helidonine ()
CHELIDONINE (+) ()
Chelidonin ()
Stylophorin, Helidonine ()
Chelidonine hydrochloride ()
P&D ID
PD078837
CAS
476-32-4
4312-31-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity[1][2][3].
PRICE 113
DESCRIPTION 1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2. (TargetMol Bioactive Compound Library)
DESCRIPTION Chelidonine hydrochloride is one of the alkaloids of Chelidonium majus, which has broad pharmacological activities (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
0
Compound Sets
6
AdooQ Bioactive Compound Library
A12147
Cayman Chemical Bioactives
25097
MedChem Express Bioactive Compound Library
HY-N2369
Other bioactive compounds
Selleckchem Bioactive Compound Library
chelidonine
TargetMol Bioactive Compound Library
T5S0055
T7324
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
353.13
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
6
Aromatic Ring Count
2
cLogP
2.33
TPSA
60.39
Fraction CSP3
0.4
Chiral centers
3.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Influenza Virus
AChR
Pathway
Anti-infection
Microbiology/virology
Source data