General
Preferred name
ciforadenant
Synonyms
V81444 ()
CPI-444 ()
Ciforadenant?(CPI-444) ()
V-81444 ()
P&D ID
PD078753
CAS
1202402-40-1
Tags
available
drug candidate
Drug indication
Advanced cancer
Attention deficit hyperactivity disorder
Parkinson disease
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ciforadenant (CPI-444) is a potent, orally active and selective adenosine A2A receptor (A2AR) antagonist, which induces antitumor responses[1].
PRICE 106
DESCRIPTION Ciforadenant (CPI-444) is an orally active adenosine A2A receptor antagonist. (GtoPdb)
DESCRIPTION CPI-444 (V81444) is an antagonist of the adenosine A2A receptor.It reduces tumor area in mouse model of murine Her2/neu-expressing breast cancer. (TargetMol Bioactive Compound Library)
Compound Sets
12
AdooQ Bioactive Compound Library
A19242
Axon Medchem Screening Library
3085
Cayman Chemical Bioactives
25024
ChEMBL Drugs
CHEMBL4297184
Drug Repurposing Hub
DrugBank
DB16125
DrugMAP
DMPWHU6
Guide to Pharmacology
10190
MedChem Express Bioactive Compound Library
HY-101978
ReFrame library
Selleckchem Bioactive Compound Library
cpi-444
TargetMol Bioactive Compound Library
T7183
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
407.17
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
4
cLogP
2.12
TPSA
127.0
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
MOA
Adenosine Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Target
A2A antagonist
Adenosine Receptor
A2A
Source data