General
Preferred name
vericiguat
Synonyms
BAY1021189 ()
BAY1021189, Verquvo ()
Verquvo ()
BAY-1021189 ()
MK-1242 ()
BAY 1021189 ()
P&D ID
PD078738
CAS
1350653-20-1
Tags
available
drug
Approved by
EMA
PMDA
FDA
First approval
2021
Drug indication
Heart failure
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.
PRICE
134
DESCRIPTION
Vericiguat is a novel oral soluble guanylate cyclase (sGC) stimulator . It was initially developed for potential to reduce mortality and morbidity associated with chronic heart failure with reduced ejection fraction.
(GtoPdb)
DESCRIPTION
Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
426.14
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
4
cLogP
2.56
TPSA
146.86
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Guanylate Cyclase
MOA
guanylate cyclase stimulant
Pathway
GPCR/G protein
Source data
