General
Preferred name
Pamiparib
Synonyms
BGB-290 ()
Pamiparib (BGB-290) ()
P&D ID
PD078591
CAS
1446261-44-4
Tags
available
drug
Drug indication
Recurrent glioblastoma
Ovarian cancer
Neoplasm
Solid tumour/cancer
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor, with IC50 values of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively. Pamiparib has potent PARP trapping, and capability to penetrate the brain, and can be used for the research of various cancers including the solid tumor[1][2].
PRICE 53
DESCRIPTION Pamiparib (BGB-290) is an orally bioavailable, selective poly (ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) inhibitor . It was developed for antineoplastic potential. PARP inhibition is used to treat tumours with defects in their DNA repair/DNA-damage response (DDR) pathway, such as BRCA 1/2 (BReast CAncer gene 1 and 2) mutations. Pamiparib can cross the blood-brain barrier, offering potential as a treatment for brain tumours . (GtoPdb)
DESCRIPTION Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor with IC50 values of 0.9 nM for PARP1 and 0.5 nM for PARP2. It exhibits strong PARP trapping, has the capability to penetrate the brain, and is used for researching various cancers, including solid tumors. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
11
Cayman Chemical Bioactives
33182
ChEMBL Drugs
CHEMBL4112930
Drug Repurposing Hub
DrugBank
DB14769
DrugMAP
DMRO6XT
EU-OPENSCREEN Bioactive Compound Library
EOS100146
EUbOPEN Chemogenomics Library
EUB0002676
Guide to Pharmacology
12345
MedChem Express Bioactive Compound Library
HY-104044
Selleckchem Bioactive Compound Library
bgb-290
TargetMol Bioactive Compound Library
T5058
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
298.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
5
Aromatic Ring Count
2
cLogP
2.08
TPSA
60.49
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
7.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PARP
PARP1
PARP2
MOA
PARP inhibitor
Pathway
Cell Cycle/DNA Damage
Epigenetics
Chromatin/Epigenetic
DNA Damage/DNA Repair
Recommended Cell Concentration
None
Source data