General
Preferred name
GYKI 53655 hydrochloride
Synonyms
LY300168 (hydrochloride) ()
GYKI 53655 (hydrochloride) ()
GYKI 53655 ()
P&D ID
PD078491
CAS
143692-48-2
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CaV1.x blocker
(Tocris Bioactive Compound Library)
DESCRIPTION
GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist displaying anticonvulsant activity. It also acts as a blocker of GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations. GYKI 53655 prolongs the survival time after MgCl2- induced global cerebral ischemia.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
11
Molecular Weight
388.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
2
cLogP
2.76
TPSA
89.18
Fraction CSP3
0.26
Chiral centers
1.0
Largest ring
7.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
AMPA Receptors
MOA
Antagonist
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
iGluR
Source data
