General
Preferred name
Gardiquimod
Synonyms
Gardiquimod (diTFA) ()
P&D ID
PD078408
CAS
1159840-61-5
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Gardiquimod diTFA is an imidazoline TLR7/8 agonist. Gardiquimod diTFA inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically activates TLR7 at concentrations below 10 ¦ÌM.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
1
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
6
Molecular Weight
541.18
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
3.31
TPSA
163.59
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Target
Toll-like Receptor (TLR)
Source data
