General
Preferred name
FANGCHINOLINE
Synonyms
Thaligine ()
(+)-Thalrugosine ()
Demethyl tetrandrine ()
(+)-Limacine, Tetrandrine B, Hanfangichin B ()
(+)-Fangchinoline ()
NSC-77036 ()
P&D ID
PD078284
CAS
33889-68-8
436-77-1
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing[1]. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK[2]. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer[3].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
6
Organisms
2
Compound Sets
3
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
608.29
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
8
Aromatic Ring Count
4
cLogP
6.86
TPSA
72.86
Fraction CSP3
0.35
Chiral centers
2.0
Largest ring
18.0
QED
0.27
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Autophagy
FAK
HIV
Pathway
Anti-infection
Protein Tyrosine Kinase/RTK
Source data
