General
Preferred name
BMS-986142
Synonyms
P&D ID
PD077887
CAS
1643368-58-4
Tags
available
drug candidate
Drug indication
Rheumatoid arthritis
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
BMS-986142 is a potent and highly selective reversible inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 0.5 nM.
PRICE
666
DESCRIPTION
BMS-986142 is a potent, highly selective and reversible small molecule BTK inhibitor , that is being investigated for anti-inflammatory potential .
(GtoPdb)
DESCRIPTION
Bruton's tyrosine kinase (BTK) is a nonreceptor tyrosine kinase. It is a member of the Tec family of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well as Fcγ receptor signaling in monocytes and Fcε receptor signaling. BMS-986142 is a potent, selective and reversible BTK inhibitor with IC50 of 0.5 nM. It potently inhibits BCR-stimulated expression of CD69 on B cells in human whole blood with IC50 of 90 nM.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
572.22
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
6
Aromatic Ring Count
5
cLogP
4.4
TPSA
123.11
Fraction CSP3
0.28
Chiral centers
1.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
BTK
MOA
Bruton's Tyrosine Kinase (BTK) Inhibitor
Pathway
Angiogenesis
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Solubility
Soluble to ≥ 120 mg/mL in DMSO
Soluble to < 1mg/mL in water.
Recommended Cell Concentration
None
Source data
