General
Preferred name
BMS-986142
Synonyms
BMS 986142 ()
BMS986142 ()
P&D ID
PD077887
CAS
1643368-58-4
Tags
available
drug candidate
Drug indication
Rheumatoid arthritis
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BMS-986142 is a potent, highly selective and reversible small molecule BTK inhibitor , that is being investigated for anti-inflammatory potential . (GtoPdb)
DESCRIPTION Bruton's tyrosine kinase (BTK) is a nonreceptor tyrosine kinase. It is a member of the Tec family of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well as Fcγ receptor signaling in monocytes and Fcε receptor signaling. BMS-986142 is a potent, selective and reversible BTK inhibitor with IC50 of 0.5 nM. It potently inhibits BCR-stimulated expression of CD69 on B cells in human whole blood with IC50 of 90 nM. (BOC Sciences Bioactive Compounds)
Compound Sets
9
BOC Sciences Bioactive Compounds
bms-986142-cas-1643368-58-4-292150
ChEMBL Drugs
CHEMBL3900554
Drug Repurposing Hub
DrugBank
DB15291
DrugMAP
DMZB8AJ
EUbOPEN Chemogenomics Library
EUB0001867
Guide to Pharmacology
9857
MedChem Express Bioactive Compound Library
HY-101856
TargetMol Bioactive Compound Library
T5138
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
572.22
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
6
Aromatic Ring Count
5
cLogP
4.4
TPSA
123.11
Fraction CSP3
0.28
Chiral centers
1.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Angiogenesis
Protein Tyrosine Kinase/RTK
Target
BTK
MOA
Bruton's Tyrosine Kinase (BTK) Inhibitor
Solubility
Soluble to ≥ 120 mg/mL in DMSO
Soluble to < 1mg/mL in water.
Recommended Cell Concentration
None
Source data