General
Preferred name
AZD9567
Synonyms
Mizacorat ()
2,2-difluoro-N-[(1R,2S)-3-methyl-1-{[1-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-indazol-5-yl]oxy}-1-phenylbutan-2-yl]propanamide ()
AZD-9567 ()
Azd 9567 ()
P&D ID
PD077838
CAS
1893415-00-3
Tags
available
drug candidate
Drug indication
Rheumatoid arthritis
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1].
PRICE 771
DESCRIPTION AZD9567 is a synthetic, selective glucocorticoid receptor (GR) partial agonist . It was designed to offer an improved side-effect profile compared to conventional full agonist GR anti-inflammatory dugs. AZD9567 is one of the chemical structures claimed in patent WO2016046260A1 . (GtoPdb)
DESCRIPTION AZD9567 is a potent and orally active and selective non-steroidal glucocorticoid receptor modulator (SGRM) with an IC50 value of 3.8 nM.It has demonstrated excellent efficacy in the Streptococcus cell wall (SCW) reactivation model of joint inflammation. (TargetMol Bioactive Compound Library)
Compound Sets
6
ChEMBL Drugs
CHEMBL4207852
DrugMAP
DMAXHC0
Guide to Pharmacology
9812
MedChem Express Bioactive Compound Library
HY-120012
ReFrame library
TargetMol Bioactive Compound Library
T14386
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
494.21
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
4
cLogP
4.64
TPSA
78.15
Fraction CSP3
0.3
Chiral centers
2.0
Largest ring
6.0
QED
0.39
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Glucocorticoid Receptor
Pathway
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Source data