General
Preferred name
THIETHYLPERAZINE MALEATE
Synonyms
Toresten ()
Norzine ()
Thiethylperazine (dimaleate) ()
Thiethylperazine dimaleate ()
GS-95 ()
NSC-130044 ()
Thietylperazine Maleate ()
Torecan ()
P&D ID
PD077801
CAS
1179-69-7
Tags
available
drug
Drug Status
approved
Max Phase
4.0
First approval
1961
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-¦Â (A¦Â) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].
PRICE 83
DESCRIPTION Thiethylperazine dimaleate (Thiethylperazine maleate) is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, anti-emetic, and antipsychotic effects. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
4
ChEMBL Approved Drugs
CHEMBL3989478
ChEMBL Drugs
CHEMBL3989478
MedChem Express Bioactive Compound Library
HY-B1794A
TargetMol Bioactive Compound Library
T17072
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
631.2
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
4
Rotatable Bonds
10
Ring Count
4
Aromatic Ring Count
2
cLogP
4.46
TPSA
158.92
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.22
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Membrane Transporter/Ion Channel
Microbiology/virology
Neuroscience
Anti-infection
Neuronal Signaling
Target
Amyloid-β
Bacterial
Dopamine Receptor
Histamine Receptor
Amyloid-¦Â
D2 receptor
H1 receptor
ABCC
Antibacterial
Source data