General
Preferred name
ROSE BENGAL SODIUM
Synonyms
PV-10 ()
Red no. 105-1 ()
Rose Bengal disodium ()
Rose bengal extra ()
Rose bengal disodium salt ()
Rose de bengala de sodio ()
Bengal rose b sodium salt ()
Acid red 94 ()
Japan red 105-1 ()
Rose bengal sodium salt ()
Rose bengale sodique ()
Aka105(1) ()
P&D ID
PD077725
CAS
24359-63-5
11121-48-5
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PV-10 is an injectable ten percent solution of rose bengal disodium, an iodinated fluorescein derivative, with potential antineoplastic and radiosensitizing activities. When injected into tumor tissue, PV-10 specifically targets and concentrates in tumor cells, producing cytotoxic singlet oxygen when exposed to ionizing radiation. In addition, PV-10 may stimulate an anti-tumor immune response.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
3
Compound Sets
4
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
EU-OPENSCREEN Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
16
Molecular Weight
1015.46
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
1.04
TPSA
93.4
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.1
Structural alerts
3
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Singlet oxygen sensitization
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Source data
