General
Preferred name
NALUZOTAN
Synonyms
PRX 00023 ()
PRX 00023 hydrochloride ()
PRX-00023 ()
Naluzotan (hydrochloride) ()
PRX 00023 (hydrochloride) ()
Naluzotan hydrochloride ()
Naluzotan hcl ()
P&D ID
PD077580
CAS
740873-06-7
740873-82-9
Tags
available
drug candidate
Drug indication
Mood disorder
temporal lobe epilepsy
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
210
DESCRIPTION
Naluzotan(PRX 00023) is a novel and potent 5-HT1A agonist with IC50 and Ki values of approximately 20 nM and 5.1 nM, respectively.Naluzotan is a potent hERG K+ channel blocker with an IC50 value of 3800 nM.Naluzotan exhibits anxiolytic activity and can be used to study depression.
PRICE
804
DESCRIPTION
Naluzotan hydrochloride (PRX 00023 hydrochloride) is a hERG K+ channel blocker with an IC50 value of 3800 nM and is commonly used in the study of anxiety and depression.Naluzotan hydrochloride is also a novel, potent, and selective 5-HT1A agonist, with an IC50 value of about 20 nM and a Ki value of about 5.1 Naluzotan hydrochloride is also a novel, potent and selective 5-HT1A agonist with an IC50 of approximately 20 nM and a Ki of approximately 5.1 nM.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
ChEMBL Drugs
DrugBank
DrugMAP
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
450.27
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
10
Ring Count
3
Aromatic Ring Count
1
cLogP
3.05
TPSA
81.75
Fraction CSP3
0.7
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT Receptor
Potassium Channel
hERG Potassium Channel
5-HT1A
Pathway
Neuronal Signaling
GPCR/G protein
Membrane Transporter/Ion Channel
Angiogenesis
JAK/STAT Signaling
Neuroscience
Tyrosine Kinase/Adaptors
Source data
