MOA Fluasterone is a synthetically stable adrenocortical steroid fluorinated analogue of dehydroepiandrosterone (DHEA), a powerful anti-inflammatory molecule with androgenic or estrogenic side effects. It is proposed that fluasterone inhibits NF-kB activation and reduces oxidative stress, but other mechanisms may play a role. Fluasterone suppresses; inflammation and is effective in preclinical models of chronic inflammatory disease including psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and lupus erythematosus. Fluasterone has anti-inflammatory effects inpreclinical models of chronic; inflammatory disease including psoriasis, asthma, rheumatoid; arthritis, multiple sclerosis and lupus erythematosus.; [Aeson Pharmaceuticals Executive Report]; ;

DESCRIPTION Fluasterone is a potent G6PD inhibitor with a Ki of 0.51 ¦ÌM. Fluasterone has anti-inflammatory, cancer preventive, and anti-diabetic effects. Fluasterone is orally active[1][2][3].