General
Preferred name
ROPIDOXURIDINE
Synonyms
IPdR ()
IPD-R ()
NSC-726188 ()
Ropidoxuridina ()
P&D ID
PD077525
CAS
93265-81-7
Tags
available
prodrug
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Lymphoma
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ropidoxuridine (IPdR) is a novel orally available, halogenated thymidine analog and is a potential radiosensitizer for use in human tumors.
PRICE 179
DESCRIPTION Ropidoxuridine is a novel, orally available 5-substituted 2-pyrimidinone-2'-deoxyribonucleoside analogue and prodrug of 5-iododeoxyuridine (IUdR). It has radiosensitizing activity. It is efficiently converted to idoxuridine (IUdR) by a hepatic aldehyde oxidase. It is incorporated into DNA during replication, thereby sensitizing cells to ionizing radiation by increasing DNA strand breaks. It is associated with a lower toxicity profile and improved anti-tumor activity. It has dose responsive and synergistic effects. It has also shown reduced toxicity, with better tissue incorporation and improved anti-tumor activity. It maybe used to treat colorectal, gastric, and pancreatic cancer, and other solid tumors. (BOC Sciences Bioactive Compounds)
DESCRIPTION Ropidoxuridine (IPdR) is a novel, orally available halogenated thymidine analogue that holds promise as a sensitizer for human tumors.Ropidoxuridine is an orally available and bioavailable IUdR (5-iodo-2'-deoxyuridine) prodrug. (TargetMol Bioactive Compound Library)
Compound Sets
6
BOC Sciences Bioactive Compounds
ropidoxuridine-cas-93265-81-7-item-100739
Cayman Chemical Bioactives
41220
ChEMBL Drugs
CHEMBL2103821
DrugBank
DB06485
MedChem Express Bioactive Compound Library
HY-13742
TargetMol Bioactive Compound Library
T16785
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
337.98
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
-0.51
TPSA
84.58
Fraction CSP3
0.56
Chiral centers
3.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
HSV
Pathway
Anti-infection
Solubility
10 mM in DMSO
Source data